Balsalazide (disodium)
Balsalazide disodium is a prodrug of amino salicylic acid that releases mesalamine in the colon, offering various anti-inflammatory effects in areas of colitis, and it also exerts related anticancer effects by regulating the IL-6/STAT3 pathway[1][2][3].
Product Specifications
CAS Number
213594-60-6
UNSPSC
12352005
Target
Interleukin Related; STAT
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC(/N=N/C2=CC=C(C(NCCC(O[Na])=O)=O)C=C2)=CC=C1O)O[Na]
Molecular Formula
C17H13N3Na2O6
Molecular Weight
401.28
References & Citations
[1]Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31 (8) :1453-61.|[2]Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49 (6) : p. 783-789.|[3]Seema A Patil, et al. Balsalazide disodium for the treatment of ulcerative colitis. Expert Rev Gastroenterol Hepatol. 2008 Apr;2 (2) :177-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
IL-6; STAT3
Frequently Asked Questions
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