OSI-7904L
OSI-7904L (GW1843) is a noncompetitive inhibitor of thymidylate synthase (TS) . OSI-7904L is an antifolate compound and a substrate for folylpolyglutamate synthetase. OSI-7904L has cytotoxicity against solid tumor lines, and the toxicity can be selectively blocked by folic acid[1].
Product Specifications
CAS Number
139987-54-5
Product Name Alternative
GW1843; 1843U89; OSI-7904
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Antifolate; Thymidylate Synthase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1C2=C3C(C=CC(CNC4=CC=C(C(N(C5)[C@H](C(O)=O)CCC(O)=O)=O)C5=C4)=C3)=CC=C2NC(C)=N1
Molecular Formula
C27H24N4O6
Molecular Weight
500.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Schwartz G, et al. A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies. Clin Cancer Res. 2001 Jul;7 (7) :1901-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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