Bisindolylmaleimide X
Bisindolylmaleimide X (Ro 31-8425, BIM-X) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X can be used for research on the immune system and cardiovascular diseases[1][2][3].
Product Specifications
CAS Number
131848-97-0
Product Name Alternative
BIM-X; Ro31-8425
UNSPSC
12352005
Hazard Statement
H301-H311-H331-H341
Target
CDK; PKC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
NCC1CCN2C(C1)=C(C3=C2C=CC=C3)C4=C(C5=CN(C)C6=CC=CC=C65)C(NC4=O)=O
Molecular Formula
C26H24N4O2
Molecular Weight
424.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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