Bitopertin (Standard)

Bitopertin (Standard) is the analytical standard of Bitopertin. This product is intended for research and analytical applications. Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.

Product Specifications

CAS Number

[845614-11-1]

UNSPSC

12352100

Target

GlyT; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

FC1=CC(C(F)(F)F)=CN=C1N2CCN(C(C3=CC(S(=O)(C)=O)=CC=C3O[C@H](C(F)(F)F)C)=O)CC2

Molecular Formula

C21H20F7N3O4S

Molecular Weight

543.46

References & Citations

[1]Alberati D, et al. Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia. Neuropharmacology. 2012 Feb;62 (2) :1152-61.|[2]Pinard E, et al. Selective GlyT1 Inhibitors: Discovery of [4- (3-Fluoro-5-trifluoromethylpyridin-2-yl) piperazin-1-yl][5-methanesulfonyl-2- ((S) -2,2,2-trifluoro-1-methylethoxy) phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia. J Me