Almorexant (Standard)
Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1] [2][3] [4].
Product Specifications
CAS Number
871224-64-5
UNSPSC
12352100
Target
Apoptosis; Calcium Channel; Caspase; Orexin Receptor (OX Receptor) ; Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer; Endocrinology; Neurological Disease
Smiles
CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
Molecular Formula
C29H31F3N2O3
Molecular Weight
512.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
TAPT1-AS1 Human qPCR Primer Pair (NM_152684)
TIMP2 (Tissue Inhibitor of Metalloproteinase 2) (rTIMP2/2335), CF488A conjugate, 0.1mg/mL
Phosphotyrosine (P-Tyr) (PY265), CF640R conjugate, 0.1mg/mL
