Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Almorexant (Standard)

Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1] [2][3] [4].

Product Specifications

CAS Number

871224-64-5

UNSPSC

12352100

Target

Apoptosis; Calcium Channel; Caspase; Orexin Receptor (OX Receptor) ; Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer; Endocrinology; Neurological Disease

Smiles

CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O

Molecular Formula

C29H31F3N2O3

Molecular Weight

512.56

References & Citations

[1]Malherbe P, et al. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1) /orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol. 2009 Sep;76 (3) :618-31.|[2]Black SW, et al. Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. Sleep. 2013 Mar 1;36 (3) :325-36.|[3]Dayot S, et al. In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma. Oncotarget. 2018 Jan 9;9 (6) :6952-6967.|[4]Dietrich H, et al. Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. Psychopharmacology (Berl) . 2010 Oct;212 (2) :145-54.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

2,6-Dichloro-4-fluorophenylboronic acid
TRC-D475213-250MG 250 mg

2,6-Dichloro-4-fluorophenylboronic acid

Sign In for Pricing
View Details
Ethyl (5-Ethyl-2-pyridinyl)acetate
TRC-E917905-5G 5 g

Ethyl (5-Ethyl-2-pyridinyl)acetate

Sign In for Pricing
View Details
SOX2 (Transcription Factor) (SOX2/1792), Biotin conjugate, 0.1mg/mL
BNCB1792-100 1x 100 µL

SOX2 (Transcription Factor) (SOX2/1792), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Individual Gel Kit Refill Buffers
CK-001 10 mL

Individual Gel Kit Refill Buffers

Sign In for Pricing
View Details
Taar5 Mouse Gene Knockout Kit (CRISPR)
KN517106 1 Kit

Taar5 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Human Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) ELISA Kit
RDR-SPLUNC2-Hu-01 96 Tests

Human Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) ELISA Kit

Sign In for Pricing
View Details