MGS 0210

MGS 0210 (BCI 838) is an orally active metabolite of glutamate receptor 2/3 (mGluR2/3) agonists. MGS 0210 improves amnesia and reduces anxiety in APP mice. MGS 0210 improves PTSD-related behaviors in a mouse model of post-traumatic stress disorder (PTSD) . MGS 0210 can be used in research on neurological disorders such as Alzheimer's disease and major depressive disorder[1][2].

Product Specifications

CAS Number

[820244-38-0]

Product Name Alternative

BCI 838

UNSPSC

12352005

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CCCCCCCOC([C@@]1([C@]2([H])[C@@]1([H])C[C@@H](OCC3=CC(Cl)=C(Cl)C=C3)[C@@]2(N)C(O)=O)F)=O

Molecular Formula

C22H28Cl2FNO5

Molecular Weight

476.37

References & Citations

[1]Kim SH, et al.. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov;19 (11) :1235-42.|[2]Tschiffely AE, et al. Blast-induced "PTSD": Evidence from an animal model. Neuropharmacology. 2019 Feb;145 (Pt B) :220-229.