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SD 8381

SD 8381 is a potent and selective COX-2 inhibitor. SD 8381 shows IC50 values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1[1].

Product Specifications

CAS Number

[215123-80-1]

UNSPSC

12352005

Target

COX

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

ClC1=C2C(C=C([C@H](O2)C(F)(F)F)C(O)=O)=CC(Cl)=C1

Molecular Formula

C11H5Cl2F3O3

Molecular Weight

313.06

References & Citations

[1]Wang JL, et al. The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. Bioorg Med Chem Lett. 2010 Dec 1;20 (23) :7155-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-2

Curated Selection

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