SD 8381
SD 8381 is a potent and selective COX-2 inhibitor. SD 8381 shows IC50 values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1[1].
Product Specifications
CAS Number
215123-80-1
UNSPSC
12352005
Target
COX
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
ClC1=C2C(C=C([C@H](O2)C(F)(F)F)C(O)=O)=CC(Cl)=C1
Molecular Formula
C11H5Cl2F3O3
Molecular Weight
313.06
References & Citations
[1]Wang JL, et al. The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. Bioorg Med Chem Lett. 2010 Dec 1;20 (23) :7155-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
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