GSK-588045
GSK-588045 is a potent 5-HT (1A/B/D) receptor antagonist. GSK-588045 shows high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channels. GSK-588045 can be used for the research of neurological disease, such as depression and anxiety[1].
Product Specifications
CAS Number
876922-98-4
UNSPSC
12352005
Target
5-HT Receptor; Potassium Channel
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=CC=C2C(C=CC=C2N3CCN(CCC4=C(OCC5=C(C(N)=O)N=CN56)C6=CC=C4)CC3)=N1
Molecular Formula
C27H28N6O2
Molecular Weight
468.55
References & Citations
[1]Bromidge SM, et al. Design and synthesis of novel tricyclic benzoxazines as potent 5-HT (1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4- (2-methyl-5-quinolinyl) -1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045) . J Med Chem. 2010 Aug 12;53 (15) :5827-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
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