Flavonol (Standard)

Flavonol (Standard) is the analytical standard of Flavonol. This product is intended for research and analytical applications. Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases[1][2][3][4].

Product Specifications

CAS Number

[577-85-5]

UNSPSC

12352100

Target

Bacterial; Cholinesterase (ChE) ; Endogenous Metabolite; Reference Standards

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Smiles

O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=CC=C13

Molecular Formula

C15H10O3

Molecular Weight

238.24

References & Citations

[1] Huang YH, et al. Inhibition of Staphylococcus aureus PriA Helicase by Flavonol Kaempferol. Protein J. 2015 Jun;34 (3) :169-72. |[2]Guo AJ, et al. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chem Biol Interact. 2010 Sep 6;187 (1-3) :246-8. |[3]Kim HK, et al. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol. 1999 Sep 1;58 (5) :759-65. |[4]Sayeli V, et al. Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice. Inflammopharmacology. 2019 Dec;27 (6) :1155-1167. |[5]Phie J, et al. Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis. PLoS One. 2017 Jul 25;12 (7) :e0181832.