4-Hydroxychalcone (Standard)

4-Hydroxychalcone (Standard) is the analytical standard of 4-Hydroxychalcone. This product is intended for research and analytical applications. 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

Product Specifications

CAS Number

[20426-12-4]

UNSPSC

12352100

Hazard Statement

H315-H319-H335-H401-H411

Target

NF-κB; Reference Standards

Related Pathways

NF-κB; Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Smiles

O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2

Molecular Formula

C15H12O2

Molecular Weight

224.25

Precautions

P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P362-P391-P403+P233-P405-P501

References & Citations

[1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.