Clodronate (disodium tetrahydrate) (Standard)

Clodronate (disodium tetrahydrate) (Standard) is the analytical standard of Clodronate (disodium tetrahydrate) . This product is intended for research and analytical applications. Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl-competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].

Product Specifications

CAS Number

[88416-50-6]

Product Name Alternative

Disodium clodronate (tetrahydrate) (Standard)

UNSPSC

12352211

Target

Others; Reference Standards

Related Pathways

Others

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Smiles

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na].O.O.O.O

Molecular Formula

CH10Cl2Na2O10P2

Molecular Weight

360.92

References & Citations

[1]Kato Y, et al. Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain. Proc Natl Acad Sci U S A. 2017 Aug 1;114 (31) :E6297-E6305.|[2]Moriyama Y, et al. Clodronate: A Vesicular ATP Release Blocker. Trends Pharmacol Sci. 2018 Jan;39 (1) :13-23.