Clodronate (disodium tetrahydrate)

Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].

Product Specifications

CAS Number

[88416-50-6]

Product Name Alternative

Disodium clodronate (tetrahydrate)

UNSPSC

12352211

Hazard Statement

H302, H319, H372, H410

Target

Others

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Purity

99.86

Solubility

H2O : 116.67 mg/mL (ultrasonic)

Smiles

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na].O.O.O.O

Molecular Formula

CH10Cl2Na2O10P2

Molecular Weight

360.92

Precautions

H302, H319, H372, H410

References & Citations

[1]Kato Y, et al. Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain. Proc Natl Acad Sci U S A. 2017 Aug 1;114 (31) :E6297-E6305.|[2]Moriyama Y, et al. Clodronate: A Vesicular ATP Release Blocker. Trends Pharmacol Sci. 2018 Jan;39 (1) :13-23.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Nat Neurosci. 2024 Aug;27 (8) :1522-1533.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|J Adv Res. 2024 Dec 9:S2090-1232 (24) 00565-4.|Phytomedicine. 2025 Mar:138:156429.