BMS-344577
BMS-344577 (Compound 22) is a potent and orally active factor Xa inhibitor (IC50 = 4 nM, EC2xPT = 7 μM) . BMS-344577 shows potent CYP3A4 inhibition activity (IC50 = 0.3 μM) . BMS-344577 can be used for the research of cardiovascular disease[1].
Product Specifications
CAS Number
288079-93-6
UNSPSC
12352005
Target
Cytochrome P450; Factor Xa
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N(CCCC1)CC(N2CCCC2)=O)[C@H]1N/C(NC(C3=CN=C(C(N(C)C)=O)C=C3)=O)=N\C4=CC=C(OC(C)=C5)C5=C4
Molecular Formula
C31H37N7O5
Molecular Weight
587.67
References & Citations
[1]Shi Y, et al. Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6882-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3A4
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