BMS-344577

BMS-344577 (Compound 22) is a potent and orally active factor Xa inhibitor (IC50 = 4 nM, EC2xPT = 7 μM) . BMS-344577 shows potent CYP3A4 inhibition activity (IC50 = 0.3 μM) . BMS-344577 can be used for the research of cardiovascular disease[1].

Product Specifications

CAS Number

[288079-93-6]

UNSPSC

12352005

Target

Cytochrome P450; Factor Xa

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C(N(CCCC1)CC(N2CCCC2)=O)[C@H]1N/C(NC(C3=CN=C(C(N(C)C)=O)C=C3)=O)=N\C4=CC=C(OC(C)=C5)C5=C4

Molecular Formula

C31H37N7O5

Molecular Weight

587.67

References & Citations

[1]Shi Y, et al. Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6882-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP3A4

Curated Selection

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