Guggulsterone (Standard)
Guggulsterone (Standard) is the analytical standard of Guggulsterone. This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-) - (E) -Guggulsterone (HY-N7781) and (Z) -Guggulsterone (HY-110066), respectively.
Product Specifications
CAS Number
95975-55-6
UNSPSC
12352100
Target
Akt; Apoptosis; Autophagy; Caspase; FXR; JNK; Reference Standards
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Molecular Formula
C21H28O2
Molecular Weight
312.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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