Guggulsterone (Standard)
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738) . This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-) - (E) -Guggulsterone (HY-N7781) and (Z) -Guggulsterone (HY-110066), respectively.
Product Specifications
CAS Number
[95975-55-6]
UNSPSC
12352100
Target
Akt; Apoptosis; Autophagy; Caspase; FXR; JNK; Reference Standards
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Molecular Formula
C21H28O2
Molecular Weight
312.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Streptococcus equi subsp. zooepidemicus Bifunctional protein FolD (folD)
Recombinant Streptococcus equi subsp. zooepidemicus Bifunctional protein FolD (folD)
Recombinant Streptococcus equi subsp. zooepidemicus Bifunctional protein FolD (folD)
Recombinant Streptococcus equi subsp. zooepidemicus Bifunctional protein FolD (folD)
Recombinant Streptococcus equi subsp. zooepidemicus Bifunctional protein FolD (folD)