NMDAR antagonist 4

NMDAR antagonist 4 (Compound 8) is the antagonist for NMDA receptor that binds NMDA receptor on glycine site with Ki >100 μM[1].

Product Specifications

CAS Number

[132623-44-0]

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC(C1=NC2=CC=CC=C2C=C1CC(O)=O)=O

Molecular Formula

C12H9NO4

Molecular Weight

231.20

References & Citations

[1]Lu T, et al., Valid and Convenient Questionnaire Assessment of Chinese Body Constitution: Item Characteristics, Reliability, and Construct Validation. Patient Prefer Adherence. 2022 Aug 2;16:1875-1884.|[2]Smith E C R, et al. Structure-activity relationships of a series of glycine antagonists related to 5, 7-dichlorokynurenic acid and 3- (2-carboxy-6-chloroindol-3-yl) acetic acid[J]. Bioorganic & Medicinal Chemistry Letters, 1993, 3 (1) : 81-84.