Kynurenic acid (sodium) (Standard)

Kynurenic acid (sodium) (Standard) is the analytical standard of Kynurenic acid (sodium) . This product is intended for research and analytical applications. Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.

Product Specifications

CAS Number

[2439-02-3]

UNSPSC

12352100

Target

Apoptosis; CXCR; Endogenous Metabolite; GPR35 ; iGluR; Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Neurological Disease; Endocrinology

Smiles

O=C(C1=NC2=CC=CC=C2C(O)=C1)O[Na]

Molecular Formula

C10H6NNaO3

Molecular Weight

211.15

References & Citations

[1]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281 (31) :22021-8.|[2]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85 (8) :1027-32.|[3]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39 (1) :6-13.