(Rac) -Atomoxetine (hydrochloride)

(Rac) -Atomoxetine hydrochloride ((Rac) -Tomoxetine (hydrochloride) ; (Rac) -LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385) . Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

Product Specifications

CAS Number

[82857-40-7]

Product Name Alternative

(Rac) -Tomoxetine (hydrochloride) ; (Rac) -LY 139603

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Serotonin Transporter; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cancer; Metabolic Disease

Smiles

CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl

Molecular Formula

C17H22ClNO

Molecular Weight

291.82

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37.|[2]Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489.|[3]Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27 (5) :699-711.