(3aS,4R,9bR) -G-1
(3aS,4R,9bR) -G-1 is a highly selective G protein-coupled receptor GPR30 (GPER) agonist with a Ki value of approximately 7 nM. (3aS,4R,9bR) -G-1 activates rapid signaling pathways such as intracellular calcium mobilization and PI3K signaling through GPR30, promoting uterine epithelial cell proliferation and exerting antidepressant effects. (3aS,4R,9bR) -G-1 is promising for research of breast cancer and depression[1].
Product Specifications
CAS Number
[925419-53-0]
UNSPSC
12352005
Target
Adhesion G Protein-coupled Receptors (AGPCRs) ; PI3K
Related Pathways
GPCR/G Protein; PI3K/Akt/mTOR
Field of Research
Cancer; Neurological Disease
Smiles
CC(C1=CC2=C(N[C@@H](C3=C(Br)C=C(OCO4)C4=C3)[C@]5([H])[C@@]2([H])C=CC5)C=C1)=O
Molecular Formula
C21H18BrNO3
Molecular Weight
412.28
References & Citations
[1]Dennis MK, et al. In vivo effects of a GPR30 antagonist. Nat Chem Biol. 2009 Jun;5 (6) :421-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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