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Propentofylline-d6

Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia[1][2].

Product Specifications

CAS Number

1216516-37-8

Product Name Alternative

HWA 285-d6

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Solubility

10 mM in DMSO

Smiles

C(CC)N1C2=C(N(C)C(=O)N(C(C(C(CC(C)=O)([2H])[2H])([2H])[2H])([2H])[2H])C2=O)N=C1

Molecular Formula

C15H16D6N4O3

Molecular Weight

312.40

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hudlicka O, Komarek J, Wright AJ. The effect of a xanthine derivative, 1- (5' oxohexyl) -3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits. Br J Pharmacol. 1981;72 (4) :723-730. |[3]Sweitzer S, De Leo J. Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. Handb Exp Pharmacol. 2011; (200) :235-250.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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