(E) -Hyzetimibe

(E) -Hyzetimibe ((E) -HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe , a cholesterol-lowering agent. (E) -Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E) -Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E) -Hyzetimibe can be used for the study of HCV infection[1][2].

Product Specifications

CAS Number

1266548-75-7

Product Name Alternative

(E) -HS-25

UNSPSC

12352005

Target

Acyltransferase; Drug Isomer; HCV

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Smiles

OC/C(C1=CC=C(C=C1)F)=C/C[C@@H]2[C@@H](C3=CC=C(C=C3)O)N(C4=CC=C(C=C4)F)C2=O

Molecular Formula

C25H21F2NO3

Molecular Weight

421.44

References & Citations

[1]BAI Y, et al. Azetidinone compound used for prevention and/or treatment of hepatitis c, and composition of the compound. WO2014131371A1|[2]BAI Y, et al. Azetidinone compounds and medical use thereof. WO2011017907.