LY2457546
LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia[1].
Product Specifications
CAS Number
908265-94-1
UNSPSC
12352005
Target
Ephrin Receptor; FLT3; PDGFR; Tie; Tyrosinase; VEGFR
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(CC1=CC=C(C2=CN=C3C=C(C4=CC(C)=NC=C4)C=CN32)C=C1F)NC5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C28H20F4N4O
Molecular Weight
504.48
References & Citations
[1]Burkholder TP, et al. Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Invest New Drugs. 2012 Jun;30 (3) :936-49.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRβ; Tie2; VEGFR2/KDR/Flk-1
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