BC-1175

BC-1175 (CB-181963) is a novel cephalosporin and antibacterial agent. CB-181963 displays strong binding to altered PBP 2a. CB-181963 demonstrates marked efficacy against MRSA, Klebsiella pneumoniae, Streptococcus pneumoniae, and Escherichia coli[1][2].

Product Specifications

CAS Number

[635292-67-0]

Product Name Alternative

CB-181963

UNSPSC

12352005

Target

Bacterial; Penicillin-binding protein (PBP)

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

OC(C1=C(/C=N/N(C)C(N2CCNCC2)=N)CS[C@@]([C@@H]3NC(/C(C4=NSC(N)=N4)=N\OCF)=O)([H])N1C3=O)=O

Molecular Formula

C19H24FN11O5S2

Molecular Weight

569.59

References & Citations

[1]Miller K, et al. Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175) . J Antimicrob Chemother. 2005 Apr;55 (4) :579-82.|[2]Huang V, et al. In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci. Antimicrob Agents Chemother. 2004 Jul;48 (7) :2719-23.