BMS-341400 (mesylate)

BMS-341400 mesylate is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 mesylate reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO) -mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 mesylate can be used to study erectile dysfunction[1][2].

Product Specifications

CAS Number

[296250-54-9]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1.CS(O)(=O)=O

Molecular Formula

C24H26ClN9O5S

Molecular Weight

588.04

References & Citations

[1]Yu G, et al. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2003 Feb 13;46 (4) :457-60. |[2]Pryor JL, Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. International journal of impotence research. 2000 Oct;12 (4) :S158-62.