BMS-341400

BMS-341400 is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO) -mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 can be used to study erectile dysfunction.

Product Specifications

CAS Number

[296250-53-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Smiles

CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1

Molecular Formula

C23H22ClN9O2

Molecular Weight

491.93

References & Citations

[1]Yu G, et al. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2003 Feb 13;46 (4) :457-60. |[2]Pryor JL, Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. International journal of impotence research. 2000 Oct;12 (4) :S158-62.