Amustaline (dihydrochloride) (Standard)

Amustaline (dihydrochloride) (Standard) is the analytical standard of Amustaline (dihydrochloride) . This product is intended for research and analytical applications. Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) [1][2].

Product Specifications

CAS Number

[210584-54-6]

Product Name Alternative

S-303 (dihydrochloride) (Standard)

UNSPSC

12352100

Target

Bacterial; CHIKV; HIV; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl.[H]Cl.[H]Cl

Molecular Formula

C22H27Cl4N3O2

Molecular Weight

507.28

References & Citations

[1]Aubry M, et, al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components. Vox Sang. 2018 Apr;113 (3) :232-241.|[2]Mufti NA, et, al. Treatment of whole blood (WB) and red blood cells (RBC) with S-303 inactivates pathogens and retains in vitro quality of stored RBC. Biologicals. 2010 Jan;38 (1) :14-9.|[3]North A, et, al. Preclinical pharmacokinetic and toxicology assessment of red blood cells prepared with S-303 pathogen inactivation treatment. Transfusion. 2011 Oct;51 (10) :2208-18.