Amustaline

Amustaline (S-303) is a compound used for inactivating pathogens in blood components and belongs to the category of nucleic acid-targeted chemical decontaminants. Amustaline has the ability to inactivate viruses and is effective against mosquito-borne viruses such as Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV) . When combined with glutathione (Glutathione, GSH), which acts as a neutralizer to counteract adverse reactions, Amustaline ensures the stability of red blood cell membranes. Amustaline is mainly used for inactivating pathogens in red blood cell concentrates (RBCC) to reduce the risk of transfusion-transmitted infections (TTI) [1][2].

Product Specifications

CAS Number

[878189-87-8]

Product Name Alternative

S-303

UNSPSC

12352005

Target

CHIKV; Dengue Virus; Flavivirus

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl

Molecular Formula

C22H25Cl2N3O2

Molecular Weight

434.36

References & Citations

[1]Aubry M, et al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components.|[2]Aydinok Y, et al. Amustaline-glutathione pathogen-reduced red blood cell concentrates for transfusion-dependent thalassaemia. Br J Haematol. 2019 Aug;186 (4) :625-636.