GR 250495X

GR 250495X is an inhaled glucocorticoid receptor agonist. GR 250495X is designed as a antedrug, which takes effect locally in the lungs but is rapidly metabolized and inactivated in the bloodstream after entering the systemic circulation, thereby minimizing systemic side effects. GR 250495X can be used in asthma research[1].

Product Specifications

CAS Number

[192057-17-3]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(OCC1)[C@H]1SC([C@]23[C@@]4([C@@]([C@@]5([H])[C@]([C@H](C4)O)([C@@]6(C([C@H](C5)F)=CC(CC6)=O)C)F)([H])C[C@@]2([H])O[C@H](O3)CCC)C)=O

Molecular Formula

C28H36F2O7S

Molecular Weight

554.64

References & Citations

[1]Sharp MJ, et al. Synthesis of Steroid'Antedrugs' for Evaluation as Safe Treatments for Asthma: Practical Synthesis of the Inhaled Steroid GR250495X.