Olcorolimus
Olcorolimus (SAR-943) is a Rapamycin (hy-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin -sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma[1].
Product Specifications
CAS Number
186752-78-3
Product Name Alternative
SAR-943
UNSPSC
12352005
Target
Drug Derivative; Interleukin Related
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Smiles
O=C1N2[C@](CCCC2)([H])C(O[C@](CC[C@@H](/C=C([C@H]([C@H](C([C@H](C)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@@]3([H])O[C@](O)([C@@H](CC3)C)C1=O)=O)OC)O)\C)C)([H])[C@H](C)C[C@H]4C[C@H]([C@H](O)CC4)OC)=O
Molecular Formula
C51H81NO12
Molecular Weight
900.19
References & Citations
[1]Fujitani Y, et al. In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am J Respir Crit Care Med. 2003 Jan 15;167 (2) :193-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-4; IL-5
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