Olcorolimus

Olcorolimus (SAR-943) is a Rapamycin (hy-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin (HY-W250978) -sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma[1].

Product Specifications

CAS Number

[186752-78-3]

Product Name Alternative

SAR-943

UNSPSC

12352005

Target

Drug Derivative; Interleukin Related

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

O=C1N2[C@](CCCC2)([H])C(O[C@](CC[C@@H](/C=C([C@H]([C@H](C([C@H](C)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@@]3([H])O[C@](O)([C@@H](CC3)C)C1=O)=O)OC)O)\C)C)([H])[C@H](C)C[C@H]4C[C@H]([C@H](O)CC4)OC)=O

Molecular Formula

C51H81NO12

Molecular Weight

900.19

References & Citations

[1]Fujitani Y, et al. In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am J Respir Crit Care Med. 2003 Jan 15;167 (2) :193-8.