ZD 9379 (sodium)
ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site) . ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc[1][2].
Product Specifications
CAS Number
[170142-29-7]
UNSPSC
12352005
Target
Glycine Receptor (GlyR) ; iGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
O=C1C2=C(C(NN1C3=C(C=C(OC)C=C3)C)=O)NC4=C(C=CC(Cl)=C4)C2=O.[Na]
Molecular Formula
C19H14ClN3NaO4
Molecular Weight
406.77
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106969A/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Caenorhabditis elegans Serine/threonine-protein kinase dkf-2 (dkf-2), partial
KIAA0427 Antibody - N-terminal region : FITC (ARP40788_P050-FITC)
Rabbit Anti MMP2 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4) (Western Blot,IHC-p,Immunofluorescence,ELISA) 200ul
