1192U90
1192U90 is an antipsychotic agent, dopamine D2 receptor antagonist as well as serotonin 5-HT1a receptor agonist. 1192U90 reduces the number of spontaneously firing neurons in the limbic dopamine system[1][2].
Product Specifications
CAS Number
155289-31-9
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=C(C=CC=C1)N)NCCCCN2CCN(C3=NSC4=C3C=CC=C4)CC2
Molecular Formula
C22H27N5OS
Molecular Weight
409.55
References & Citations
[1]Dillberger JE, et al. The experimental antipsychotic agent 1192U90 targets tapetum lucidum in canine eyes. Toxicol Pathol. 1996 Sep-Oct;24 (5) :595-601. |[2]Norman MH, et al. Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. J Med Chem. 1996 Mar 1;39 (5) :1172-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT1 Receptor; D2 Receptor
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