Mazapertine

Mazapertine is an orally active antipsychotic agent. M azapertine antagonizes to dopamine D2/3/4 receptors (Ki values 5-HT1A receptor (Ki =1.7 nM) and α1-adrenergic receptor (Ki = 1.3 nM) . Mazapertine can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[134208-17-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(C)OC1=C(N2CCN(CC3=CC(C(N4CCCCC4)=O)=CC=C3)CC2)C=CC=C1

Molecular Formula

C26H35N3O2

Molecular Weight

421.58

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Reitz AB, et al. Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem. 1998 Jun 4;41 (12) :1997-2009.