U 93385
U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism[1].
Product Specifications
CAS Number
[147145-16-2]
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
NC(C1=C2[C@@]3([H])[C@](CCC2=CC=C1)([H])N(CCC)CC3)=O
Molecular Formula
C16H22N2O
Molecular Weight
258.36
References & Citations
[1]McCall RB, et al. Rapid and long duration tolerance to the vagal bradycardic effects of 5-HT1A receptor agonists. Behav Brain Res. 1996;73 (1-2) :297-300.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT1 Receptor
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