SM 10888

SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. SM 10888 can increase brain acetylcholine release. SM 10888 can be used for the research of neurological disease, such as Alzheimer's disease[1][2].

Product Specifications

CAS Number

[129297-21-8]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

NC1=C(C(F)=CC=C2)C2=NC3=C1CC4CC3C4.OC(C(O)=O)(CC(O)=O)CC(O)=O

Molecular Formula

C20H21FN2O7

Molecular Weight

420.39

References & Citations

[1]Xu M, et al. Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease. Neurosci Lett. 1991 Feb 25;123 (2) :179-82.|[2]Okazaki Y, et al. Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice. Jpn J Pharmacol. 1990 Jun;53 (2) :211-20.