BRL 34778

BRL 34778 is a potent, selective and orally active dopamine D2 receptor antagonist with a Ki of 2.14 nM. BRL 34778 exhibits antipsychotic activity with low activity for extrapyramidal effects and sedation. BRL 34778 can be used for the research of neurological disease, such as schizophrenia[1].

Product Specifications

CAS Number

[86580-77-0]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=C(C=C(N)C(Cl)=C1)OC)N[C@@H](C[C@@H]2CCC3)C[C@@H]3N2CC4=CC=C(F)C=C4

Molecular Formula

C23H27ClFN3O2

Molecular Weight

431.93

References & Citations

[1]Brown F, et al. The selective dopamine antagonist properties of BRL 34778: a novel substituted benzamide. Psychopharmacology (Berl) . 1988;94 (3) :350-8.