OPC-4392

OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480) -induced dopamine accumulation, inhibits Apomorphine (HY-12723) -induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent[1][2].

Product Specifications

CAS Number

[111073-34-8]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CC(C(C)=CC=C1)=C1N(CC2)CCN2CCCOC3=CC=C(C=CC4=O)C(N4)=C3

Molecular Formula

C24H29N3O2

Molecular Weight

391.51

References & Citations

[1]Yasuda Y, et al. 7-[3- (4-[2,3-Dimethylphenyl]piperazinyl) propoxy]-2 (1H) -quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. Life Sci. 1988;42 (20) :1941-54.|[2]Murasaki M, et al. Phase 1 study of a new antipsychotic drug, OPC-4392. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12 (5) :793-802.