Trimelamol
Trimelamol (CB10-375; NSC283162) is a highly efficient acid-catalyzed DNA interstrand crosslinker with low neurotoxicity due to its limited BBB penetration. Trimelamol exhibits anti-tumor activity and overcomes platinum resistance. Trimelamol is investigated for lung and ovarian cancer research[1][2][3][4][5].
Product Specifications
CAS Number
64124-21-6
Product Name Alternative
CB 10-375; NSC 283162
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
OCN(C1=NC(N(C)CO)=NC(N(C)CO)=N1)C
Molecular Formula
C9H18N6O3
Molecular Weight
258.28
References & Citations
[1]I R Judson, et al. Phase I trial and pharmacokinetics of trimelamol (N2, N4, N6-trihydroxymethyl-N2, N4, N6-trimethylmelamine) . Cancer Res. 1989 Oct 1;49 (19) :5475-9.|[2]I R Judson, et al. Low central nervous system penetration of N2, N4, N6, -trihydroxymethyl-N2, N4, N6, -trimethylmelamine (Trimelamol) : a cytotoxic s-triazine with reduced neurotoxicity. Br J Cancer. 1986 May;53 (5) :601-6.|[3]C Jackson, et al. N2, N4, N6-tri (hydroxymethyl) -N2, N4, N6-trimethylmelamine (trimelamol) is an efficient DNA cross-linking agent in vitro. Biochem Pharmacol. 1991 Nov 6;42 (11) :2091-7.|[4]H M Coley, et al. Pre-clinical development of the anti-tumour agent CB 7646, bis N- (hydroxymethyl) trimethylmelamine, a stable analogue of trimelamol. Int J Cancer. 1996 Nov 4;68 (3) :356-63.|[5]Y Yamada, et al. Antitumor effect of trimelamol against human breast carcinoma xenografts in nude mice. Oncol Rep. 1996 Jul;3 (4) :613-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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