Urotensin-II receptor antagonist-1
Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor) . Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM) [1].
Product Specifications
CAS Number
1034708-07-0
UNSPSC
12352005
Target
Cytochrome P450; Opioid Receptor; Sodium Channel; Urotensin Receptor
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CN(CC(N1[C@@H](CN2CCCC2)[C@@H](C3=CC=CC=C3)CCC1)=O)C4=CC=C(Cl)C(Cl)=C4
Molecular Formula
C25H31Cl2N3O
Molecular Weight
460.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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