Taprostene (sodium)
Taprostene sodium is a partial agonist at prostanoid prostacyclin (IP) receptors. Taprostene sodium interacts additively with Prostaglandin E2 (PGE2) , ONO-AE1-259 (selective EP2 agonist), and acetylcholine. Taprostene sodium exerts a significant cardioprotection[1].
Product Specifications
CAS Number
87440-45-7
Product Name Alternative
CG 4203 (sodium)
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
NAChR; Prostaglandin Receptor
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O[C@@H](C1CCCCC1)/C=C/[C@@H]2[C@]3([H])[C@@](C[C@H]2O)([H])O/C(C3)=C\C4=CC(C(O[Na])=O)=CC=C4
Molecular Formula
C24H29NaO5
Molecular Weight
420.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Chan KM, et al. Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43 (6) :795-807.|[2]Johnson G, et al. Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats. Circ Res. 1990 May;66 (5) :1362-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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