Voclosporin-d4

Voclosporin-d4 (ISAtx-247-d4) is deuterium labeled Voclosporin. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor[1].

Product Specifications

Product Name Alternative

ISAtx-247-d4

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Molecular Glues; Phosphatase

Related Pathways

Metabolic Enzyme/Protease; Others; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C[C@H](C/C=C([2H])/C([2H])=C([2H])/[2H])[C@H]([C@]1([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)O

Molecular Formula

C63H107D4N11O12

Molecular Weight

1218.65

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20 (2) :161.|[3]Stalder M, et al. In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates. J Heart Lung Transplant. 2003 Dec;22 (12) :1343-52.