TEI-6122

TEI-6122 is a 7-thiaprostaglandin E1 derivative. TEI-6122 can reduce urinary protein and suppressthe increase of blood urea nitrogen. TEI-6122 can inhibit monocyte chemoattractant protein-1 induced chemotaxis. TEI-6122 can be used for the research of inflammation, such as nephritis[1][2].

Product Specifications

CAS Number

[83058-69-9]

Product Name Alternative

TFC 612

UNSPSC

12352100

Target

Drug Derivative

Related Pathways

Others

Field of Research

Inflammation/Immunology

Smiles

COC(CCCCCS[C@@H]1[C@H]([C@H](O)CC1=O)/C=C/[C@@H](O)C[C@H](C)CCCC)=O

Molecular Formula

C22H38O5S

Molecular Weight

414.60

References & Citations

[1]Nagamatsu T, et al. Antinephritic effects of PGE1 and thiaprostaglandin E1, TEI-5178 and TEI-6122, on crescentic-type anti-GBM nephritis in rats. Jpn J Pharmacol. 1989 Dec;51 (4) :521-30.|[2]Tanaka H, et al. The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells. Br J Pharmacol. 1995 Oct;116 (4) :2298-302.