Flumezapine
Flumezapine (LY 120363) is a potent and balanced antagonist of the dopamine D2 receptor and the 5-hydroxytryptamine receptor (5-HT receptor) . Flumezapine does not alter the increase in serum cortisol caused by κ-opioid receptor agonists. Flumezapine inhibits the conditioned avoidance response in rats and has a low risk of extrapyramidal side effects. Flumezapine can be used in antipsychotic research[1][2].
Product Specifications
CAS Number
61325-80-2
Product Name Alternative
LY 120363
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
FC1=CC2=C(NC3=C(C(N4CCN(CC4)C)=N2)C=C(C)S3)C=C1
Molecular Formula
C17H19FN4S
Molecular Weight
330.42
References & Citations
[1]Fuller RW, Mason NR. Flumezapine, an antagonist of central dopamine and serotonin receptors. Res Commun Chem Pathol Pharmacol. 1986 Oct;54 (1) :23-34.|[2]Fuller RW, Snoddy HD. Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats. J Pharm Pharmacol. 1985 Oct;37 (10) :755-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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