Lortalamine

Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC50 of [1][2].

Product Specifications

CAS Number

[70384-91-7]

Product Name Alternative

LM 1404

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Monoamine Transporter

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=C1N[C@@]23[C@@](CN(CC3)C)([H])[C@](C1)([H])C4=CC(Cl)=CC=C4O2

Molecular Formula

C15H17ClN2O2

Molecular Weight

292.76

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lin KS, et al. Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R) -nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons. Bioorg Med Chem. 2005 Aug 1;13 (15) :4658-66. |[2]Depin JC, et al. Pharmacology of lortalamine, a new potent non-tricyclic antidepressant. Arzneimittelforschung. 1985;35 (11) :1655-62.