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Picenadol (hydrochloride)

Picenadol (LY-150720) hydrochloride is an opioid mixed agonist-antagonist analgesic. Picenadol hydrochloride is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol hydrochloride has anticholinergic activity[1][2].

Product Specifications

CAS Number

74685-16-8

Product Name Alternative

LY-150720 (hydrochloride)

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CCC[C@@]1(C2=CC(O)=CC=C2)[C@H](CN(C)CC1)C.Cl

Molecular Formula

C16H26ClNO

Molecular Weight

283.84

References & Citations

[1]Carter RB, et al. Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey. Pharmacol Biochem Behav. 1984 Nov;21 (5) :779-86.|[2]Zimmerman DM, et al. Picenadol. Drug Alcohol Depend. 1985 Feb;14 (3-4) :381-401.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

μ Opioid Receptor/MOR

Frequently Asked Questions

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