Proterguride

Proterguride is a potent dopamine receptor agonist. Proterguride also shows antagonistic properties at the histamine H (1) receptor and alpha (1) -adrenoceptor and partially agonize serotonergic 5-HT2A/B receptor. Proterguride can be used for the research of neurological disease, such as Parkinson's disease [1].

Product Specifications

CAS Number

[77650-95-4]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CCCN1[C@@](C2)([H])[C@@](C[C@H](NC(N(CC)CC)=O)C1)([H])C3=C4C2=CNC4=CC=C3

Molecular Formula

C22H32N4O

Molecular Weight

368.52

References & Citations

[1]Schurad B, et al. Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha (1) -, 5-HT (2) - and H (1) -receptors. Life Sci. 2006 Apr 11;78 (20) :2358-64.