BCX-5

BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology[1][2].

Product Specifications

CAS Number

[132138-76-2]

Product Name Alternative

PD 141955

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Inflammation/Immunology

Smiles

O=C(NC(N)=N1)C2=C1C(CC3=CSC=C3)=CN2

Molecular Formula

C11H10N4OS

Molecular Weight

246.29

References & Citations

[1]Gilbertsen RB, et al. Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955. Biochem Pharmacol. 1992 Sep 1;44 (5) :996-9.|[2]Wilburn DJ, et al. PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR) . Agents Actions. 1993;39 Spec No:C96-8.