BCX-5
BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology[1][2].
Product Specifications
CAS Number
132138-76-2
Product Name Alternative
PD 141955
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Smiles
O=C(NC(N)=N1)C2=C1C(CC3=CSC=C3)=CN2
Molecular Formula
C11H10N4OS
Molecular Weight
246.29
References & Citations
[1]Gilbertsen RB, et al. Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955. Biochem Pharmacol. 1992 Sep 1;44 (5) :996-9.|[2]Wilburn DJ, et al. PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR) . Agents Actions. 1993;39 Spec No:C96-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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