SGB-1534 (hydrochloride)

SGB-1534 hydrochloride is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 hydrochloride can inhibit vasoconstriction and lower blood pressure. SGB-1534 hydrochloride can be used for the research of cardiovascular disease, such as hypertension[1][2].

Product Specifications

CAS Number

[88068-72-8]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(N1CCN2CCN(C3=C(C=CC=C3)OC)CC2)C4=CC=CC=C4NC1=O.Cl

Molecular Formula

C21H25ClN4O3

Molecular Weight

416.90

References & Citations

[1]Aono J, et al. Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors. Arch Int Pharmacodyn Ther. 1985 Sep;277 (1) :126-39.|[2]Nabata H, et al. Antihypertensive effects of a novel phenylpiperazine derivative, SGB-1534, on several hypertensive models of rats. Arch Int Pharmacodyn Ther. 1985 Sep;277 (1) :104-18.