SGB-1534 (hydrochloride)
SGB-1534 hydrochloride is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 hydrochloride can inhibit vasoconstriction and lower blood pressure. SGB-1534 hydrochloride can be used for the research of cardiovascular disease, such as hypertension[1][2].
Product Specifications
CAS Number
88068-72-8
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(N1CCN2CCN(C3=C(C=CC=C3)OC)CC2)C4=CC=CC=C4NC1=O.Cl
Molecular Formula
C21H25ClN4O3
Molecular Weight
416.90
References & Citations
[1]Aono J, et al. Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors. Arch Int Pharmacodyn Ther. 1985 Sep;277 (1) :126-39.|[2]Nabata H, et al. Antihypertensive effects of a novel phenylpiperazine derivative, SGB-1534, on several hypertensive models of rats. Arch Int Pharmacodyn Ther. 1985 Sep;277 (1) :104-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; α adrenergic receptor
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