Benzylacyclouridine (Standard)

Benzylacyclouridine (Standard) is the analytical standard of Benzylacyclouridine. This product is intended for research and analytical applications. Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives[1][2][3].

Product Specifications

CAS Number

[82857-69-0]

Product Name Alternative

BAU (Standard) ; 5-Benzylacyclouridine (Standard)

UNSPSC

12352005

Target

Drug Derivative; Reference Standards

Related Pathways

Others

Field of Research

Cancer

Smiles

OCCOCN(C(NC1=O)=O)C=C1CC2=CC=CC=C2

Molecular Formula

C14H16N2O4

Molecular Weight

276.29

References & Citations

[1]Pizzorno G, et, al. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. Clin Cancer Res. 1998 May;4 (5) :1165-75.|[2]Roosild TP, et, al. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. BMC Struct Biol. 2009 Mar 16;9:14.|[3]Monks A, et, al. Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver. Biochem Pharmacol. 1983 Jul 1;32 (13) :2003-9.